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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ivb 1J5 Tyrosine-protein kinase JAK1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ivb 1J5Tyrosine-protein kinase JAK1 / 0.999
4ivc 1J6Tyrosine-protein kinase JAK1 / 0.940
4ivd 15TTyrosine-protein kinase JAK1 / 0.935
4iva 1J5Tyrosine-protein kinase JAK2 / 0.878
4ei4 0Q2Tyrosine-protein kinase JAK1 / 0.797
4e4l 0NHTyrosine-protein kinase JAK1 / 0.785
4f09 JAKTyrosine-protein kinase JAK2 / 0.761
4f08 1RSTyrosine-protein kinase JAK2 / 0.746
4e5w 0NTTyrosine-protein kinase JAK1 / 0.719
4e6d 0NUTyrosine-protein kinase JAK2 / 0.717
4fk6 0UJTyrosine-protein kinase JAK1 / 0.695
4ehz JAKTyrosine-protein kinase JAK1 / 0.673
4ft7 H3KSerine/threonine-protein kinase Chk1 2.7.11.1 0.668
3elj GS7Mitogen-activated protein kinase 8 2.7.11.24 0.653
4e4m 0NHTyrosine-protein kinase JAK2 / 0.651