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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4i1n FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4i1n FOLDihydrofolate reductase 1.5.1.3 1.048
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.913
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.909
4i13 FOLDihydrofolate reductase 1.5.1.3 0.904
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.863
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.860
4kjj FOLDihydrofolate reductase 1.5.1.3 0.848
1dyi FOLDihydrofolate reductase 1.5.1.3 0.841
4x5g FOLDihydrofolate reductase 1.5.1.3 0.840
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.837
4m6k FOLDihydrofolate reductase 1.5.1.3 0.836
1dyh DZFDihydrofolate reductase 1.5.1.3 0.833
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.830
3tqb FOLDihydrofolate reductase / 0.829
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.826
2zza FOLDihydrofolate reductase / 0.823
7dfr FOLDihydrofolate reductase 1.5.1.3 0.823
1dyj DDFDihydrofolate reductase 1.5.1.3 0.818
4kfj FOLDihydrofolate reductase 1.5.1.3 0.816
1dls MTXDihydrofolate reductase 1.5.1.3 0.813
4x5f FOLDihydrofolate reductase 1.5.1.3 0.812
4keb FOLDihydrofolate reductase 1.5.1.3 0.802
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.795
1drf FOLDihydrofolate reductase 1.5.1.3 0.789
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.789
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.787
3drc MTXDihydrofolate reductase 1.5.1.3 0.786
3dau MTXDihydrofolate reductase 1.5.1.3 0.783
4x5h FOLDihydrofolate reductase 1.5.1.3 0.783
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.782
1dre MTXDihydrofolate reductase 1.5.1.3 0.781
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.781
5hi6 MTXDihydrofolate reductase / 0.781
3ghw GHWDihydrofolate reductase 1.5.1.3 0.780
4dfr MTXDihydrofolate reductase 1.5.1.3 0.780
1jom FFODihydrofolate reductase 1.5.1.3 0.775
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.774
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.774
1dhf FOLDihydrofolate reductase 1.5.1.3 0.770
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.767
3och 2MXDihydrofolate reductase 1.5.1.3 0.765
5ccc DDFDihydrofolate reductase 1.5.1.3 0.764
4fhb FOLDihydrofolate reductase 1.5.1.3 0.761
1re7 FOLDihydrofolate reductase 1.5.1.3 0.760
2w3m FOLDihydrofolate reductase 1.5.1.3 0.760
4x5i FOLDihydrofolate reductase 1.5.1.3 0.760
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.759
2d0k FOLDihydrofolate reductase 1.5.1.3 0.758
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.758
1hfq MOTDihydrofolate reductase 1.5.1.3 0.756
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.750
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.749
3ia4 MTXDihydrofolate reductase / 0.748
3frd DHFDihydrofolate reductase 1.5.1.3 0.746
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.744
1dhj MTXDihydrofolate reductase 1.5.1.3 0.744
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.744
1dra MTXDihydrofolate reductase 1.5.1.3 0.743
1df7 MTXDihydrofolate reductase 1.5.1.3 0.742
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.741
3dfr MTXDihydrofolate reductase 1.5.1.3 0.740
4p66 MTXDihydrofolate reductase / 0.736
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.733
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.732
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.729
1hfp MOTDihydrofolate reductase 1.5.1.3 0.728
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.727
3tq9 MTXDihydrofolate reductase / 0.726
3eig MTXDihydrofolate reductase 1.5.1.3 0.723
4qi9 MTXDihydrofolate reductase / 0.723
2qk8 MTXDihydrofolate reductase / 0.722
1hfr MOTDihydrofolate reductase 1.5.1.3 0.717
1u72 MTXDihydrofolate reductase 1.5.1.3 0.714
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.713
1ohk COPDihydrofolate reductase 1.5.1.3 0.710
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.708
1ohj COPDihydrofolate reductase 1.5.1.3 0.707
1tdr MTXDihydrofolate reductase 1.5.1.3 0.707
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.706
4m6l 21VDihydrofolate reductase 1.5.1.3 0.706
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.704
1e26 GPBDihydrofolate reductase 1.5.1.3 0.703
2drc MTXDihydrofolate reductase 1.5.1.3 0.703
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.692
1u70 MTXDihydrofolate reductase 1.5.1.3 0.691
1dhi MTXDihydrofolate reductase 1.5.1.3 0.682
3aej AA5Methionine gamma-lyase / 0.681
3ghv GHCDihydrofolate reductase 1.5.1.3 0.681
1drb MTXDihydrofolate reductase 1.5.1.3 0.669
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.668
1jol FFODihydrofolate reductase 1.5.1.3 0.661
1x28 PGUAspartate aminotransferase 2.6.1.1 0.661
4p68 MTXDihydrofolate reductase / 0.661
4c13 UMLUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase / 0.660
1toj HCIAspartate aminotransferase 2.6.1.1 0.659
1odn APVIsopenicillin N synthase 1.21.3.1 0.658
1toi HCIAspartate aminotransferase 2.6.1.1 0.655
3rt8 CWDGlutamate receptor 3 / 0.655
1w06 W05Isopenicillin N synthase 1.21.3.1 0.652
1qiq ACCIsopenicillin N synthase 1.21.3.1 0.651
2qs1 UB1Glutamate receptor ionotropic, kainate 1 / 0.651
3exf TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.651
3exf TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.651
2ay3 MPPAromatic-amino-acid aminotransferase 2.6.1.57 0.650