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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4i0s 1B5 Tyrosine-protein kinase SYK 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4i0s 1B5Tyrosine-protein kinase SYK 2.7.10.2 0.863
3zc6 VFCTyrosine-protein kinase JAK3 2.7.10.2 0.690
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.668
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.663
4e5f 0N7Polymerase acidic protein / 0.660
4ez3 0S0Cyclin-dependent kinase 2 2.7.11.22 0.658
1h7u AGSMismatch repair endonuclease PMS2 3.1 0.654
4jik 1KOSerine/threonine-protein kinase Chk1 2.7.11.1 0.650