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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ha9 NDP 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase 1.1.1.302

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ha9 NDP2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase 1.1.1.302 1.179
3dga NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.736
4kl9 NDPDihydrofolate reductase 1.5.1.3 0.735
2d5n NDPRiboflavin biosynthesis protein RibD 1.1.1.193 0.728
1dg8 NDPDihydrofolate reductase 1.5.1.3 0.717
3qls NDPDihydrofolate reductase 1.5.1.3 0.715
1rx1 NAPDihydrofolate reductase 1.5.1.3 0.713
2cig 1DGDihydrofolate reductase 1.5.1.3 0.682
1drh NAPDihydrofolate reductase 1.5.1.3 0.666
3kjr NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.664
3inv NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.658
1ra3 NAPDihydrofolate reductase 1.5.1.3 0.657
2w3b NDPDihydrofolate reductase 1.5.1.3 0.650