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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4h5e YS4 Farnesyl pyrophosphate synthase 2.5.1.10

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4h5e YS4Farnesyl pyrophosphate synthase 2.5.1.10 1.283
4h5d YS4Farnesyl pyrophosphate synthase 2.5.1.10 1.275
4lfv YS4Farnesyl pyrophosphate synthase 2.5.1.10 1.271
4h5c YS4Farnesyl pyrophosphate synthase 2.5.1.10 1.233
4dem YS4Farnesyl pyrophosphate synthase 2.5.1.10 1.201
4kqs RISFarnesyl pyrophosphate synthase 2.5.1.10 0.945
2f94 BFQFarnesyl pyrophosphate synthase 2.5.1.10 0.944
4q23 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.944
4l2x YL2Farnesyl pyrophosphate synthase 2.5.1.10 0.938
3icz PB6Farnesyl pyrophosphate synthase / 0.932
4dxj 0M9Farnesyl pyrophosphate synthase / 0.923
4nke RISFarnesyl pyrophosphate synthase 2.5.1.10 0.916
3rye UNRFarnesyl pyrophosphate synthase 2.5.1.10 0.912
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.910
4dwb 0M7Farnesyl pyrophosphate synthase / 0.909
3ez3 ZOLFarnesyl pyrophosphate synthase, putative / 0.902
4ga3 4GAFarnesyl pyrophosphate synthase 2.5.1.10 0.881
1yv5 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.864
3dyh 721Farnesyl pyrophosphate synthase / 0.858
3egt 722Farnesyl pyrophosphate synthase / 0.858
3ldw ZOLFarnesyl pyrophosphate synthase, putative / 0.831
1zw5 ZOLFarnesyl pyrophosphate synthase 2.5.1.10 0.802
1yq7 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.786
2o1o RISPutative farnesyl pyrophosphate synthase / 0.782
2zev B71Geranylgeranyl pyrophosphate synthase / 0.762
2i19 1BYFarnesyl pyrophosphate synthase / 0.750
2e8w IPEGeranylgeranyl pyrophosphate synthase / 0.710
2z52 H23Geranylgeranyl pyrophosphate synthase / 0.693
3ryw K9HFarnesyl pyrophosphate synthase, putative / 0.690
2z4y 252Geranylgeranyl pyrophosphate synthase / 0.689
3oab DSTGeranyl diphosphate synthase large subunit / 0.689
5erm 210Fusicoccadiene synthase 4.2.3.43 0.687
2e91 ZOLGeranylgeranyl pyrophosphate synthase / 0.685
3krf DSTGeranyl diphosphate synthase large subunit / 0.675
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
4h2i A125'-nucleotidase 3.1.3.5 0.670
5ero 210Fusicoccadiene synthase 2.5.1.29 0.669
1kxp ATPActin, alpha skeletal muscle / 0.668
4to0 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.666
1a5u ATPPyruvate kinase PKM 2.7.1.40 0.663
1khe GCPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.662
3mhy ATPNitrogen regulatory protein P-II 1 / 0.662
3n0z 3ATAdenylate cyclase 2 / 0.661
2xul ATPNitrogen regulatory protein P-II / 0.660
4to3 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.660
1esn ANPPantothenate kinase 2.7.1.33 0.659
4brd ANPEctonucleoside triphosphate diphosphohydrolase I / 0.658
4brg GNPEctonucleoside triphosphate diphosphohydrolase I / 0.658
4qfx DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.658
4qfy DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.658
2q36 ATPActin, alpha skeletal muscle / 0.657
3mle ADPATP-dependent dethiobiotin synthetase BioD 6.3.3.3 0.657
4mkf AP5Adenylate kinase / 0.654
2z4z SC0Geranylgeranyl pyrophosphate synthase / 0.653
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.652
3au2 DGTDNA polymerase beta family (X family) / 0.651
4jvj 1MVFarnesyl pyrophosphate synthase 2.5.1.10 0.651
4z54 GDPNeuronal-specific septin-3 / 0.651
2qx7 NAPEugenol synthase 1 1.1.1.318 0.650
2r5t ANPSerine/threonine-protein kinase Sgk1 2.7.11.1 0.650
2y6p CTP3-deoxy-manno-octulosonate cytidylyltransferase 2.7.7.38 0.650