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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4h3f 10O Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4h3f 10OBeta-secretase 1 3.4.23.46 0.977
4h3j 10WBeta-secretase 1 3.4.23.46 0.764
4h3g 10QBeta-secretase 1 3.4.23.46 0.705
4h3i 10VBeta-secretase 1 3.4.23.46 0.689
4b1d 6TGBeta-secretase 1 3.4.23.46 0.688
4b70 WM9Beta-secretase 1 3.4.23.46 0.670
4b05 32DBeta-secretase 1 3.4.23.46 0.667
4azy 7F3Beta-secretase 1 3.4.23.46 0.665
4b1e 6T6Beta-secretase 1 3.4.23.46 0.653
4b77 54MBeta-secretase 1 3.4.23.46 0.652