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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4h0n SAH Dnmt2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4h0n SAHDnmt2 / 0.945
10mh SAHModification methylase HhaI 2.1.1.37 0.720
7mht SAHModification methylase HhaI 2.1.1.37 0.704
2uyh SAHModification methylase HhaI 2.1.1.37 0.700
1skm SAHModification methylase HhaI 2.1.1.37 0.686
2c7q SAHModification methylase HhaI 2.1.1.37 0.685
5il2 SAHN6-adenosine-methyltransferase 70 kDa subunit / 0.683
1mht SAHModification methylase HhaI 2.1.1.37 0.681
2i9k SAHModification methylase HhaI 2.1.1.37 0.675
2bzg SAHThiopurine S-methyltransferase 2.1.1.67 0.674
3mht SAHModification methylase HhaI 2.1.1.37 0.673
2g1p SAHDNA adenine methylase 2.1.1.72 0.669
4dkj SAHCytosine-specific methyltransferase / 0.666
3go4 SAHUncharacterized protein / 0.664
4gbe SAHDNA adenine methylase 2.1.1.72 0.663
5e72 SAMN2, N2-dimethylguanosine tRNA methyltransferase / 0.663
1fjx SAHModification methylase HhaI 2.1.1.37 0.662
4dmg SAMUncharacterized protein / 0.661
3wdm ADN4-phosphopantoate--beta-alanine ligase 6.3.2.36 0.659
2zth SAMCatechol O-methyltransferase 2.1.1.6 0.658
5e9w SAHmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.658
3axt SAMtRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase / 0.657
2zcj SAHModification methylase HhaI 2.1.1.37 0.656
5k7u SAMN6-adenosine-methyltransferase 70 kDa subunit / 0.656
2yx1 SFGtRNA (guanine(37)-N1)-methyltransferase Trm5b 2.1.1.228 0.653
4qdk SAHMagnesium-protoporphyrin O-methyltransferase 2.1.1.11 0.652
3u81 SAHCatechol O-methyltransferase 2.1.1.6 0.651
1g60 SAMModification methylase MboII 2.1.1.72 0.650
4pyn SAHCatechol O-methyltransferase 2.1.1.6 0.650