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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4gva ADP Mitogen-activated protein kinase 1 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4gva ADPMitogen-activated protein kinase 1 2.7.11.24 0.839
4m15 ADPTyrosine-protein kinase ITK/TSK 2.7.10.2 0.693
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.686
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.678
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.677
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.670
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.668
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.666
4lv5 ADPRhoptry protein 5B / 0.665
5la6 ACPTubulin tyrosine ligase / 0.665
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.664
2w5b AGSSerine/threonine-protein kinase Nek2 2.7.11.1 0.664
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.663
4dt8 ADNAPH(2'')-Id / 0.663
3ac1 KZITyrosine-protein kinase Lck 2.7.10.2 0.660
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.656
4hl1 ZZ7Metallo-beta-lactamase type 2 / 0.656
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.655
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.653
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.652
3t1k ANPHeat shock protein HSP 90-alpha / 0.651
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.650