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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4gtl FAD Flavin-dependent thymidylate synthase 2.1.1.148

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4gtl FADFlavin-dependent thymidylate synthase 2.1.1.148 1.332
5ios FADFlavin-dependent thymidylate synthase 2.1.1.148 0.985
4gte FADFlavin-dependent thymidylate synthase 2.1.1.148 0.978
3n0b FADFlavin-dependent thymidylate synthase 2.1.1.148 0.954
3g4a FADFlavin-dependent thymidylate synthase 2.1.1.148 0.952
3n0c FADFlavin-dependent thymidylate synthase 2.1.1.148 0.928
1o29 FADFlavin-dependent thymidylate synthase 2.1.1.148 0.918
4kar FADFlavin-dependent thymidylate synthase 2.1.1.148 0.861
4p5a FADFlavin-dependent thymidylate synthase / 0.815
4p5b FADFlavin-dependent thymidylate synthase / 0.785
2af6 FADFlavin-dependent thymidylate synthase 2.1.1.148 0.774
2gq2 NAPFlavin-dependent thymidylate synthase 2.1.1.148 0.742
1kq4 FADFlavin-dependent thymidylate synthase 2.1.1.148 0.719
3gwc FADFlavin-dependent thymidylate synthase 2.1.1.148 0.713
1uda UFGUDP-glucose 4-epimerase 5.1.3.2 0.677
3hzg FADFlavin-dependent thymidylate synthase 2.1.1.148 0.670
3ah5 FADFlavin-dependent thymidylate synthase 2.1.1.148 0.668
4wx1 FDAUDP-galactopyranose mutase / 0.660
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.659
4u8k FDAUDP-galactopyranose mutase / 0.654