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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4gg1 TZD Benzoylformate decarboxylase 4.1.1.7

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4gg1 TZDBenzoylformate decarboxylase 4.1.1.7 1.131
4gm0 TZDBenzoylformate decarboxylase 4.1.1.7 1.072
5dgt TZDBenzoylformate decarboxylase 4.1.1.7 1.071
4jd5 TZDBenzoylformate decarboxylase 4.1.1.7 1.053
4mq5 TPPBenzoylformate decarboxylase 4.1.1.7 1.053
4ju9 TZDBenzoylformate decarboxylase 4.1.1.7 1.052
2fwn TDPBenzoylformate decarboxylase 4.1.1.7 1.051
1po7 TZDBenzoylformate decarboxylase 4.1.1.7 1.038
4qel TZDBenzoylformate decarboxylase 4.1.1.7 1.033
4gm4 TZDBenzoylformate decarboxylase 4.1.1.7 1.031
3fsj D7KBenzoylformate decarboxylase 4.1.1.7 1.028
4jub TPPBenzoylformate decarboxylase 4.1.1.7 1.026
4ju8 TZDBenzoylformate decarboxylase 4.1.1.7 1.020
4mzx TZDBenzoylformate decarboxylase 4.1.1.7 1.018
3fzn D7KBenzoylformate decarboxylase 4.1.1.7 1.010
4gm1 TZDBenzoylformate decarboxylase 4.1.1.7 0.999
4mpp TZDBenzoylformate decarboxylase 4.1.1.7 0.985
4mpr TPPBenzoylformate decarboxylase 4.1.1.7 0.982
4juf TPPBenzoylformate decarboxylase 4.1.1.7 0.981
1bfd TPPBenzoylformate decarboxylase 4.1.1.7 0.979
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 0.968
2v3w TPPBenzoylformate decarboxylase 4.1.1.7 0.942
4juc TPPBenzoylformate decarboxylase 4.1.1.7 0.898
1mcz TDPBenzoylformate decarboxylase 4.1.1.7 0.880
4k9p TPPBenzoylformate decarboxylase 4.1.1.7 0.868
4k9o TPPBenzoylformate decarboxylase 4.1.1.7 0.866
2q5q TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.822
4cok TPPPyruvate decarboxylase / 0.822
3hwx TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.795
2vk8 TPPPyruvate decarboxylase isozyme 1 / 0.783
1pox TPPPyruvate oxidase 1.2.3.3 0.776
1pyd TDPPyruvate decarboxylase isozyme 1 / 0.774
4zp1 TPPPyruvate decarboxylase 4.1.1.1 0.772
1y9d TPPPyruvate oxidase 1.2.3.3 0.769
1pvd TPPPyruvate decarboxylase isozyme 1 / 0.764
1pow TPPPyruvate oxidase 1.2.3.3 0.763
5ej9 TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.759
5c4i TPPOxalate oxidoreductase subunit alpha / 0.758
5c4i TPPOxalate oxidoreductase subunit beta / 0.758
2ji7 OXTOxalyl-CoA decarboxylase 4.1.1.8 0.756
1kek HTLPyruvate synthase / 0.754
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.752
2q5o TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.751
2ezt TDMPyruvate oxidase 1.2.3.3 0.750
2w93 TPPPyruvate decarboxylase isozyme 1 / 0.749
5eja TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.749
2vk4 TPPPyruvate decarboxylase 4.1.1.1 0.741
5ahk TPPAcetolactate synthase II, large subunit / 0.739
5ej4 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.739
2pan TDPGlyoxylate carboligase 4.1.1.47 0.738
5esd TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.737
2jlc TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.728
5ej7 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.728
5eso TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.722
1ols TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.719
2x7j TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.719
2ji6 TPWOxalyl-CoA decarboxylase 4.1.1.8 0.716
2qta TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.716
1rp7 TZDPyruvate dehydrogenase E1 component 1.2.4.1 0.715
3iae D7KBenzaldehyde lyase / 0.713
2jib TPPOxalyl-CoA decarboxylase 4.1.1.8 0.711
2jla TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.710
2uz1 TPPBenzaldehyde lyase / 0.710
1ovm TPPIndole-3-pyruvate decarboxylase 4.1.1.74 0.704
1umc TDP2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4 0.704
1umc TDP2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4 0.704
5ej6 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.703
1v11 TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.697
2qtc TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.697
2ez9 TDKPyruvate oxidase 1.2.3.3 0.696
1ni4 TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.692
1ni4 TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.692
4qpz TPPBenzaldehyde lyase / 0.690
1l8a TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.688
2o1s TDP1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 0.685
2c3y HTLPyruvate synthase / 0.683
2g28 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.682
3d7k D7KBenzaldehyde lyase / 0.678
5ej8 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.676
2j9f THV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.669
2j9f THV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 1.2.4.4 0.669
2g25 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.668
5ej5 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.668
1ih8 APCNH(3)-dependent NAD(+) synthetase 6.3.1.5 0.666
3exh TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.666
3exh TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.666
2ihu TP9N(2)-(2-carboxyethyl)arginine synthase / 0.664
3duf R1TPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.662
3duf R1TPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.662
3ahe THDProbable phosphoketolase / 0.661
3eya TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.661
3lq2 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.661
2fju GSPRas-related C3 botulinum toxin substrate 1 / 0.659
4mkf AP5Adenylate kinase / 0.659
2ag0 TPPBenzaldehyde lyase / 0.658
3ey9 TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.658
2c5l GTPGTPase HRas / 0.657
3tkl GTPRas-related protein Rab-1A / 0.657
3zhq TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.657
3dva TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.656
3dva TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.656
3iaf TPPBenzaldehyde lyase / 0.656
1itz TPPTransketolase, chloroplastic 2.2.1.1 0.655
1khe GCPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.652
1th8 ADPAnti-sigma F factor / 0.652
5itz GTPTubulin alpha-1B chain / 0.651
2e8w IPEGeranylgeranyl pyrophosphate synthase / 0.650