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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fx3 60K Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fx3 60KCyclin-dependent kinase 2 2.7.11.22 1.104
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.810
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.804
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.801
1ke5 LS1Cyclin-dependent kinase 2 2.7.11.22 0.783
1e9h INRCyclin-dependent kinase 2 2.7.11.22 0.782
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.763
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.758
1ke8 LS4Cyclin-dependent kinase 2 2.7.11.22 0.752
4fkq 42KCyclin-dependent kinase 2 2.7.11.22 0.740
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.735
4fkw 62KCyclin-dependent kinase 2 2.7.11.22 0.734
3mtl FEFCyclin-dependent kinase 16 2.7.11.22 0.731
1fvt 106Cyclin-dependent kinase 2 2.7.11.22 0.722
1ke6 LS2Cyclin-dependent kinase 2 2.7.11.22 0.718
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.713
1unh IXMCyclin-dependent-like kinase 5 2.7.11.1 0.697
2qkr IXMCdc2-like CDK2/CDC28 like protein kinase / 0.694
4c59 FEFCyclin-G-associated kinase 2.7.11.1 0.692
1ke9 LS5Cyclin-dependent kinase 2 2.7.11.22 0.691
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.690
3r8p Z46Cyclin-dependent kinase 2 2.7.11.22 0.684
2vz6 FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha 2.7.11.17 0.677
1uv5 BRWGlycogen synthase kinase-3 beta 2.7.11.26 0.676
3i5z Z48Mitogen-activated protein kinase 1 2.7.11.24 0.676
4qmt H1NSerine/threonine-protein kinase 24 2.7.11.1 0.674
3c7q XINVascular endothelial growth factor receptor 2 2.7.10.1 0.671
3rmf 20ZCyclin-dependent kinase 2 2.7.11.22 0.669
3say OFTGlycogen synthase kinase-3 beta 2.7.11.26 0.669
3r6x X84Cyclin-dependent kinase 2 2.7.11.22 0.668
3tiz 3TICyclin-dependent kinase 2 2.7.11.22 0.668
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.668
2pe0 39Z3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.658
3rpo 24ZCyclin-dependent kinase 2 2.7.11.22 0.658
3hzt J60Calmodulin-like domain protein kinase isoform 3 / 0.656
2c6k DT2Cyclin-dependent kinase 2 2.7.11.22 0.655
1pmv 537Mitogen-activated protein kinase 10 2.7.11.24 0.654
2pe1 5173-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.653
3s1h 56ZCyclin-dependent kinase 2 2.7.11.22 0.653
4gu9 4GUFocal adhesion kinase 1 2.7.10.2 0.653
5dq8 FLFTranscriptional enhancer factor TEF-4 / 0.651