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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fv9 E71 Mitogen-activated protein kinase 1 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fv9 E71Mitogen-activated protein kinase 1 2.7.11.24 0.959
5hes 032Mitogen-activated protein kinase kinase kinase 20 2.7.11.25 0.706
3biz 61EWee1-like protein kinase 2.7.10.2 0.690
3cqe P91Wee1-like protein kinase 2.7.10.2 0.686
4fuy EK2Mitogen-activated protein kinase 1 2.7.11.24 0.686
2z2w 770Wee1-like protein kinase 2.7.10.2 0.684
2in6 839Wee1-like protein kinase 2.7.10.2 0.679
3bi6 396Wee1-like protein kinase 2.7.10.2 0.677
2hzi JINTyrosine-protein kinase ABL1 2.7.10.2 0.676
2b1p AIZMitogen-activated protein kinase 10 2.7.11.24 0.672
4otw DB8Receptor tyrosine-protein kinase erbB-3 2.7.10.1 0.668
3erk SB4Mitogen-activated protein kinase 1 2.7.11.24 0.666
4hnf 16WCasein kinase I isoform delta 2.7.11.1 0.665
1wzy F29Mitogen-activated protein kinase 1 2.7.11.24 0.659
4fv7 E94Mitogen-activated protein kinase 1 2.7.11.24 0.659
1tvo FRZMitogen-activated protein kinase 1 2.7.11.24 0.653
1pme SB2Mitogen-activated protein kinase 1 2.7.11.24 0.651
3fi3 JK2Mitogen-activated protein kinase 10 2.7.11.24 0.650