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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fv4 EK7 Mitogen-activated protein kinase 1 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fv4 EK7Mitogen-activated protein kinase 1 2.7.11.24 0.929
4fv6 E57Mitogen-activated protein kinase 1 2.7.11.24 0.716
3i60 E86Mitogen-activated protein kinase 1 2.7.11.24 0.672
2b55 D31Cyclin-dependent kinase 2 2.7.11.22 0.664
4d4s BI9Focal adhesion kinase 1 2.7.10.2 0.664
4bb4 32WEphrin type-B receptor 4 2.7.10.1 0.661
2xch CKG3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.654
4d58 BI9Focal adhesion kinase 1 2.7.10.2 0.651