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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ft7 H3K Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ft7 H3KSerine/threonine-protein kinase Chk1 2.7.11.1 0.936
4ft9 H4KSerine/threonine-protein kinase Chk1 2.7.11.1 0.725
2i0y 5CNMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.723
2e9p 77ASerine/threonine-protein kinase Chk1 2.7.11.1 0.719
2b7a IZATyrosine-protein kinase JAK2 / 0.689
3eyh IZATyrosine-protein kinase JAK1 / 0.673
4ftc H6KSerine/threonine-protein kinase Chk1 2.7.11.1 0.672
2e9u A25Serine/threonine-protein kinase Chk1 2.7.11.1 0.669
4ivb 1J5Tyrosine-protein kinase JAK1 / 0.668
4ivc 1J6Tyrosine-protein kinase JAK1 / 0.664
4f08 1RSTyrosine-protein kinase JAK2 / 0.659
2e9v 85ASerine/threonine-protein kinase Chk1 2.7.11.1 0.658
3c7q XINVascular endothelial growth factor receptor 2 2.7.10.1 0.655
2ym3 YM3Serine/threonine-protein kinase Chk1 2.7.11.1 0.654
4qmt H1NSerine/threonine-protein kinase 24 2.7.11.1 0.651