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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4elf 35I Dihydrofolate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4elf 35IDihydrofolate reductase / 1.237
4ele 31IDihydrofolate reductase / 0.983
3fl8 RARDihydrofolate reductase / 0.938
3m08 RARDihydrofolate reductase 1.5.1.3 0.849
4fgg 0U5Dihydrofolate reductase 1.5.1.3 0.834
4elg 52JDihydrofolate reductase / 0.822
4elh 53IDihydrofolate reductase / 0.805
4elb 34SDihydrofolate reductase / 0.800
2w9h TOPDihydrofolate reductase 1.5.1.3 0.751
3fyw XCFDihydrofolate reductase 1.5.1.3 0.738
3sru Q26Dihydrofolate reductase 1.5.1.3 0.728
3fyv XCFDihydrofolate reductase 1.5.1.3 0.722
3jw5 TOPDihydrofolate reductase / 0.715
3m09 RARDihydrofolate reductase 1.5.1.3 0.706
4elb 34RDihydrofolate reductase / 0.700
4fgh 0U6Dihydrofolate reductase 1.5.1.3 0.673
1dra MTXDihydrofolate reductase 1.5.1.3 0.670
4g8z TOPDihydrofolate reductase 1.5.1.3 0.667
3ia4 MTXDihydrofolate reductase / 0.662
4dfr MTXDihydrofolate reductase 1.5.1.3 0.661
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.660
1klk PMDDihydrofolate reductase 1.5.1.3 0.658
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.658
1tdr MTXDihydrofolate reductase 1.5.1.3 0.657
3och 2MXDihydrofolate reductase 1.5.1.3 0.657
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.655
3jw3 TOPDihydrofolate reductase / 0.650
3tq9 MTXDihydrofolate reductase / 0.650