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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ef9 FMN Dihydroorotate dehydrogenase (fumarate)

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 1.130
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 1.126
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 1.121
3gye FMNDihydroorotate dehydrogenase (fumarate) / 1.101
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.096
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 1.079
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.064
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.060
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.023
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 1.018
3oix FMNDihydroorotate dehydrogenase / 0.948
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.934
1z41 FMNNADPH dehydrogenase / 0.860
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.849
4tmb FMNOld yellow enzyme / 0.844
3l5l FMNXenobiotic reductase / 0.841
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.839
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.837
3hf3 FMNChromate reductase / 0.834
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.831
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.825
1gwj FMNMorphinone reductase / 0.824
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.823
3n14 FMNXenobiotic reductase / 0.819
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.817
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.802
4e2d FMNDehydrogenase / 0.799
4e2b FMNDehydrogenase / 0.796
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.793
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.788
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.787
3aty FMNProstaglandin F2a synthase / 0.772
2zfa FMNLactate oxidase / 0.770
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.767
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.761
3p82 FMNPentaerythritol tetranitrate reductase / 0.759
3p8i FMNPentaerythritol tetranitrate reductase / 0.758
4jic FMNGTN Reductase / 0.755
4m5p FMNNADPH dehydrogenase / 0.754
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.750
3tjl FMNNADPH dehydrogenase / 0.750
5ebu FMNLactate oxidase / 0.750
1h50 FMNPentaerythritol tetranitrate reductase / 0.741
3p8j FMNPentaerythritol tetranitrate reductase / 0.740
2du2 FMNLactate oxidase / 0.739
3p74 FMNPentaerythritol tetranitrate reductase / 0.731
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.731
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.731
2z6i FMN2-nitropropane dioxygenase / 0.729
3f03 FMNPentaerythritol tetranitrate reductase / 0.729
1ep1 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.728
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.724
4df2 FMNNADPH dehydrogenase / 0.724
4yl2 FMNLactate oxidase / 0.723
1h51 FMNPentaerythritol tetranitrate reductase / 0.721
1h63 FMNPentaerythritol tetranitrate reductase / 0.721
3p84 FMNPentaerythritol tetranitrate reductase / 0.718
3n19 FNRXenobiotic reductase / 0.711
4qai FMNNADPH dehydrogenase / 0.705
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.703
4rje FNRLactate oxidase / 0.702
3gr8 FMNNADPH dehydrogenase / 0.700
2e77 FMNLactate oxidase / 0.699
3gka FMNN-ethylmaleimide reductase / 0.697
3p62 FMNPentaerythritol tetranitrate reductase / 0.697
4yco FMNtRNA-dihydrouridine(16) synthase / 0.694
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.693
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.691
4uth FMNXenobiotic reductase / 0.691
4utm FNRXenobiotic reductase / 0.690
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.689
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.687
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.681
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.679
3n3b FMNProtein NrdI / 0.678
5cpm FNRNADH:flavin oxidoreductase / 0.678
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.676
2h8x FMNXenA / 0.675
4cw5 FMNDfnA / 0.675
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.674
3hji FADVivid PAS protein VVD / 0.673
3p67 FMNPentaerythritol tetranitrate reductase / 0.672
1vyr FMNPentaerythritol tetranitrate reductase / 0.671
2abb FMNPentaerythritol tetranitrate reductase / 0.671
3atz FMNProstaglandin F2a synthase / 0.671
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.666
4utl FNRXenobiotic reductase / 0.665
3w77 FMNFMN-dependent NADH-azoreductase / 0.664
4u8m FDAUDP-galactopyranose mutase / 0.664
2ohj FMNType A flavoprotein FprA 1 0.662
1z48 FMNNADPH dehydrogenase / 0.661
4n65 FMNFMN-dependent NADH-azoreductase 1 / 0.661
1kfc IPLTryptophan synthase alpha chain / 0.658
4zoh FADPutative oxidoreductase FAD-binding subunit / 0.658
1r2j FADFkbI / 0.657
3l67 FMNXenobiotic reductase / 0.656
4qoe FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.654
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.653
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.652
4qof FMNRibosyldihydronicotinamide dehydrogenase [quinone] / 0.652
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.651
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.651