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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4eb7 PLP Cysteine desulfurase IscS 2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4eb7 PLPCysteine desulfurase IscS 2 / 0.934
4eb5 PLPCysteine desulfurase IscS 2 / 0.859
1map KETAspartate aminotransferase, mitochondrial 2.6.1.1 0.695
4wxg 2BOSerine hydroxymethyltransferase / 0.687
4zm3 PLPAminotransferase / 0.683
2fq6 P3FCystathionine beta-lyase MetC 4.4.1.8 0.678
3vax PLPUncharacterized protein / 0.678
1cq8 PY6Aspartate aminotransferase 2.6.1.1 0.675
4wxf PLGSerine hydroxymethyltransferase / 0.675
4itx IN5Cystathionine beta-lyase MetC 4.4.1.8 0.673
4obu PLPPyridoxal-dependent decarboxylase domain protein / 0.669
1arh PPDAspartate aminotransferase 2.6.1.1 0.668
1x28 PGUAspartate aminotransferase 2.6.1.1 0.666
1mlz PLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase 2.6.1.62 0.665
1cq7 PY5Aspartate aminotransferase 2.6.1.1 0.664
2bwp PLG5-aminolevulinate synthase 2.3.1.37 0.663
2ykv IK2Beta-transaminase / 0.659
1cl2 PPGCystathionine beta-lyase MetC 4.4.1.8 0.657
3zrr PXGSerine-pyruvate aminotransferase (AgxT) / 0.657
1oxo IK2Aspartate aminotransferase, mitochondrial 2.6.1.1 0.655
4fl0 PLPAminotransferase ALD1, chloroplastic 2.6.1 0.653
4w5k PLPAspartate aminotransferase, mitochondrial / 0.653