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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4eb5 PLP Cysteine desulfurase IscS 2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4eb5 PLPCysteine desulfurase IscS 2 / 0.932
4eb7 PLPCysteine desulfurase IscS 2 / 0.859
2gqn BLPCystathionine beta-lyase MetC 4.4.1.8 0.702
2bwp PLG5-aminolevulinate synthase 2.3.1.37 0.697
4wxg 2BOSerine hydroxymethyltransferase / 0.696
4w5k PLPAspartate aminotransferase, mitochondrial / 0.695
4zm3 PLPAminotransferase / 0.687
2fq6 P3FCystathionine beta-lyase MetC 4.4.1.8 0.683
4obu PLPPyridoxal-dependent decarboxylase domain protein / 0.681
4fl0 PLPAminotransferase ALD1, chloroplastic 2.6.1 0.676
1map KETAspartate aminotransferase, mitochondrial 2.6.1.1 0.674
1x28 PGUAspartate aminotransferase 2.6.1.1 0.673
1dfo PLGSerine hydroxymethyltransferase 2.1.2.1 0.671
3vax PLPUncharacterized protein / 0.662
1akb PPDAspartate aminotransferase, mitochondrial 2.6.1.1 0.661
4itx IN5Cystathionine beta-lyase MetC 4.4.1.8 0.661
1oxo IK2Aspartate aminotransferase, mitochondrial 2.6.1.1 0.655
1cl2 PPGCystathionine beta-lyase MetC 4.4.1.8 0.653