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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4e93 GUI Tyrosine-protein kinase Fes/Fps 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4e93 GUITyrosine-protein kinase Fes/Fps 2.7.10.2 1.189
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 0.795
4d4s BI9Focal adhesion kinase 1 2.7.10.2 0.757
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.710
4brx KGWFocal adhesion kinase 1 2.7.10.2 0.702
4d58 BI9Focal adhesion kinase 1 2.7.10.2 0.694
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.689
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.685
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.682
2wip P49Cyclin-dependent kinase 2 2.7.11.22 0.672
4bbf O19Tyrosine-protein kinase JAK2 / 0.671
3elj GS7Mitogen-activated protein kinase 8 2.7.11.24 0.669
2j9m PY8Cyclin-dependent kinase 2 2.7.11.22 0.667
3et7 349Protein-tyrosine kinase 2-beta 2.7.10.2 0.665
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.663
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.663
2x9f X9FEphrin type-B receptor 4 2.7.10.1 0.662
4dea NHIAurora kinase A 2.7.11.1 0.660
2x6d X6DAurora kinase A 2.7.11.1 0.657
4grb 0XGCasein kinase II subunit alpha 2.7.11.1 0.657
5dr6 SKEAurora kinase A 2.7.11.1 0.655
3nup 3NUCyclin-dependent kinase 6 2.7.11.22 0.652