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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4e7r 0NW Prothrombin 3.4.21.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4e7r 0NWProthrombin 3.4.21.5 1.233
1ypk CCRProthrombin 3.4.21.5 0.845
2zda 32UProthrombin 3.4.21.5 0.809
4ax9 N5NProthrombin 3.4.21.5 0.808
1ypm RA4Prothrombin 3.4.21.5 0.804
4baq M4ZProthrombin 3.4.21.5 0.802
2zg0 50UProthrombin 3.4.21.5 0.793
7kme ACE_0BN_CHG_PRRProthrombin 3.4.21.5 0.783
2ziq 26UProthrombin 3.4.21.5 0.781
3v0x ANHCationic trypsin 3.4.21.4 0.778
3hat GLY_VAL_ARG_RNGProthrombin 3.4.21.5 0.767
3utu 1TSProthrombin 3.4.21.5 0.765
2znk 31UProthrombin 3.4.21.5 0.760
3biv 11UProthrombin 3.4.21.5 0.757
2cf9 348Prothrombin 3.4.21.5 0.749
1ype UIPProthrombin 3.4.21.5 0.747
2zhf 49UProthrombin 3.4.21.5 0.747
2zgx 29UProthrombin 3.4.21.5 0.742
2zhe 13UProthrombin 3.4.21.5 0.742
1riw OSCProthrombin 3.4.21.5 0.740
4ayy 9MXProthrombin 3.4.21.5 0.736
2anm CDOProthrombin 3.4.21.5 0.734
4bam MM9Prothrombin 3.4.21.5 0.731
1nzq 162Prothrombin 3.4.21.5 0.729
1oyt FSNProthrombin 3.4.21.5 0.727
4ayv 9MQProthrombin 3.4.21.5 0.725
1c5n ESIProthrombin 3.4.21.5 0.724
4bak M67Prothrombin 3.4.21.5 0.724
2zi2 24UProthrombin 3.4.21.5 0.723
1lpk CBBCoagulation factor X 3.4.21.6 0.722
4fuj 1U9Urokinase-type plasminogen activator 3.4.21.73 0.722
2bok 784Coagulation factor X 3.4.21.6 0.721
1sqt UI3Urokinase-type plasminogen activator 3.4.21.73 0.720
2cf8 ESHProthrombin 3.4.21.5 0.720
1d4p BPPProthrombin 3.4.21.5 0.719
1owe 675Urokinase-type plasminogen activator 3.4.21.73 0.717
3biu 10UProthrombin 3.4.21.5 0.717
4fub 4UPUrokinase-type plasminogen activator 3.4.21.73 0.712
1wtg 3BPCoagulation factor VII 3.4.21.21 0.708
1z71 L17Prothrombin 3.4.21.5 0.707
1uvs I11Prothrombin 3.4.21.5 0.704
1k21 IGNProthrombin 3.4.21.5 0.703
1ypg UIRProthrombin 3.4.21.5 0.703
2bdy UNBProthrombin 3.4.21.5 0.703
1mu8 CDBProthrombin 3.4.21.5 0.700
1owk 303Urokinase-type plasminogen activator 3.4.21.73 0.700
1c4v IH2Prothrombin 3.4.21.5 0.699
1o0d 163Prothrombin 3.4.21.5 0.697
4fud 6UPUrokinase-type plasminogen activator 3.4.21.73 0.696
1ypj UIBProthrombin 3.4.21.5 0.695
1sl3 170Prothrombin 3.4.21.5 0.689
4fuf 8UPUrokinase-type plasminogen activator 3.4.21.73 0.687
1mue CDDProthrombin 3.4.21.5 0.686
1sb1 165Prothrombin 3.4.21.5 0.686
2zfr 46UProthrombin 3.4.21.5 0.685
2a2x NA9Prothrombin 3.4.21.5 0.684
1c4u IH1Prothrombin 3.4.21.5 0.682
4lxb 7R9Prothrombin 3.4.21.5 0.679
2g00 4QCCoagulation factor X 3.4.21.6 0.677
2zfq 45UProthrombin 3.4.21.5 0.675
4fui UI3Urokinase-type plasminogen activator 3.4.21.73 0.675
3kqe LGMCoagulation factor X 3.4.21.6 0.674
1f92 UKPUrokinase-type plasminogen activator 3.4.21.73 0.672
2zhw 12UProthrombin 3.4.21.5 0.672
1t4u 81AProthrombin 3.4.21.5 0.670
4loy 6XSProthrombin 3.4.21.5 0.670
1mu6 CDAProthrombin 3.4.21.5 0.668
1a4w QWEProthrombin 3.4.21.5 0.667
1ae8 AZLProthrombin 3.4.21.5 0.665
2v3o I26Prothrombin 3.4.21.5 0.665
2v3h I25Prothrombin 3.4.21.5 0.663
4fue 7UPUrokinase-type plasminogen activator 3.4.21.73 0.662
1ghv 120Prothrombin 3.4.21.5 0.661
1zgi 382Prothrombin 3.4.21.5 0.658
2y82 930Coagulation factor X 3.4.21.6 0.657
3c1k T15Prothrombin 3.4.21.5 0.655
1wqv PSMCoagulation factor VII 3.4.21.21 0.653
2zp0 PI0Coagulation factor VII 3.4.21.21 0.652
4jpe 1M7Beta-secretase 1 3.4.23.46 0.652