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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dp3 MMV Bifunctional dihydrofolate reductase-thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4dp3 MMVBifunctional dihydrofolate reductase-thymidylate synthase / 1.234
1j3i WRABifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.744
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.742
4dph P65Bifunctional dihydrofolate reductase-thymidylate synthase / 0.731
1hfp MOTDihydrofolate reductase 1.5.1.3 0.669
1ohj COPDihydrofolate reductase 1.5.1.3 0.666
1j3k WRABifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.665
1dg7 WRBDihydrofolate reductase 1.5.1.3 0.663
1dra MTXDihydrofolate reductase 1.5.1.3 0.663
3inv C50Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.663
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.657
3fpa DTBATP-dependent dethiobiotin synthetase BioD / 0.655
2c3d COM2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.652
1hfr MOTDihydrofolate reductase 1.5.1.3 0.650