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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4djv 0KM Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4djv 0KMBeta-secretase 1 3.4.23.46 0.971
4djw 0KPBeta-secretase 1 3.4.23.46 0.844
4b0q GMFBeta-secretase 1 3.4.23.46 0.843
4acu QN7Beta-secretase 1 3.4.23.46 0.810
4djy 0KRBeta-secretase 1 3.4.23.46 0.792
4djx 0KQBeta-secretase 1 3.4.23.46 0.790
4jpc 1M6Beta-secretase 1 3.4.23.46 0.776
4b72 2FBBeta-secretase 1 3.4.23.46 0.759
4jp9 1M5Beta-secretase 1 3.4.23.46 0.742
4joo 1M4Beta-secretase 1 3.4.23.46 0.738
4fs4 H24Beta-secretase 1 3.4.23.46 0.729
4jpe 1M7Beta-secretase 1 3.4.23.46 0.727
4acx S8ZBeta-secretase 1 3.4.23.46 0.716
4b05 32DBeta-secretase 1 3.4.23.46 0.716
4b1c 1B1Beta-secretase 1 3.4.23.46 0.700
4b70 WM9Beta-secretase 1 3.4.23.46 0.693
2va6 H24Beta-secretase 1 3.4.23.46 0.691
4azy 7F3Beta-secretase 1 3.4.23.46 0.687
4b1d 6TGBeta-secretase 1 3.4.23.46 0.675
4b1e 6T6Beta-secretase 1 3.4.23.46 0.666
1c5n ESIProthrombin 3.4.21.5 0.662
4b00 I6XBeta-secretase 1 3.4.23.46 0.658