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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ct1 ATP 3-phosphoinositide-dependent protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ct1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.789
4rqk ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.748
4xx9 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.742
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.734
2biy ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.728
4rqv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.721
4aw0 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.714
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.707
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.705
3hrc ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.684
5ack ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.676
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.660
1h1w ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.659
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.659
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.658
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.652