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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c35 NU3 cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4c35 NU3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.055
5auw QUEDeath-associated protein kinase 1 2.7.11.1 0.709
4ftl H0KSerine/threonine-protein kinase Chk1 2.7.11.1 0.686
3nuy JPZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.667
2c3k ABOSerine/threonine-protein kinase Chk1 2.7.11.1 0.664
4e5l DBHPolymerase acidic protein / 0.660
4ftk H9KSerine/threonine-protein kinase Chk1 2.7.11.1 0.657
5auu LU2Death-associated protein kinase 1 2.7.11.1 0.656
4fst HK4Serine/threonine-protein kinase Chk1 2.7.11.1 0.655
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.654
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.651