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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bup SAM Histone-lysine N-methyltransferase KMT5B 2.1.1.43

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bup SAMHistone-lysine N-methyltransferase KMT5B 2.1.1.43 1.157
3s8p SAMHistone-lysine N-methyltransferase KMT5B 2.1.1.43 1.060
4au7 SAHHistone-lysine N-methyltransferase KMT5C 2.1.1.43 0.886
4ynp SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.722
5jhn SAMHistone-lysine N-methyltransferase EHMT2 / 0.713
3ooi SAMHistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific 2.1.1.43 0.712
3qwp SAMHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.711
5jj0 SAMHistone-lysine N-methyltransferase EHMT2 / 0.711
2r3a SAMHistone-lysine N-methyltransferase SUV39H2 2.1.1.43 0.700
4ynm SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.695
3pdn SFGHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.690
4bw9 ANPPyrrolysine--tRNA ligase / 0.690
2h21 SAMRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.685
5hq8 SAHHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.680
4j83 SAMHistone-lysine N-methyltransferase SETD7 2.1.1.43 0.669
1ozv SAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.665
4ype SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.664
1p0y SAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.663
3tg4 SAMN-lysine methyltransferase SMYD2 / 0.661
1ifu FMCRicin 3.2.2.22 0.656
5f59 SAHHistone-lysine N-methyltransferase 2C 2.1.1.43 0.656
3swc SAHHistone-lysine N-methyltransferase EHMT1 / 0.655
2zdg ADPD-alanine--D-alanine ligase / 0.654
2h23 SAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.651
2igq SAHHistone-lysine N-methyltransferase EHMT1 / 0.651
3mey ATPAmino acid--[acyl-carrier-protein] ligase 1 6.2.1.n2 0.650