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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4aov NAP Isocitrate dehydrogenase [NADP]

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4aov NAPIsocitrate dehydrogenase [NADP] / 1.034
2cmj NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.947
2cmv NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.920
4umy NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.910
4umx NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.904
4l04 NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.857
1t0l NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.851
4l06 NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.823
3inm NDPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.821
4kzo NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.797
2qfx NDPIsocitrate dehydrogenase [NADP], mitochondrial 1.1.1.42 0.755
4l03 NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.745
4f7i NAD3-isopropylmalate dehydrogenase 1.1.1.85 0.741
1xkd NAPIsocitrate dehydrogenase [NADP] / 0.732
3flk NAITartrate dehydrogenase/decarboxylase 1.1.1.93 0.727
2d4v NADIsocitrate dehydrogenase [NADP] / 0.716
4wuo NAD3-isopropylmalate dehydrogenase 1.1.1.85 0.709
2qfv NAPIsocitrate dehydrogenase [NADP], mitochondrial 1.1.1.42 0.707
2d1c NAPIsocitrate dehydrogenase [NADP] 1.1.1.42 0.690
4xxv NAD3-isopropylmalate dehydrogenase / 0.675
1t09 NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.671
2y42 NAD3-isopropylmalate dehydrogenase 1.1.1.85 0.661