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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3zc6 VFC Tyrosine-protein kinase JAK3 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3zc6 VFCTyrosine-protein kinase JAK3 2.7.10.2 0.862
4e5i 0N9Polymerase acidic protein / 0.744
4i0s 1B5Tyrosine-protein kinase SYK 2.7.10.2 0.690
4hvi 19STyrosine-protein kinase JAK3 2.7.10.2 0.688
4hvg 19QTyrosine-protein kinase JAK3 2.7.10.2 0.674
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.667
4hvh 19RTyrosine-protein kinase JAK3 2.7.10.2 0.663
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.661
3blq ATPCyclin-dependent kinase 9 2.7.11.22 0.655
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.652
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.651
4q5j ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.650