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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3tq8 TOP Dihydrofolate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3tq8 TOPDihydrofolate reductase / 1.011
3fre TOPDihydrofolate reductase 1.5.1.3 0.859
1dyr TOPDihydrofolate reductase 1.5.1.3 0.826
4m7v RARDihydrofolate reductase / 0.749
2w3v TOPDihydrofolate reductase / 0.748
3fra I2HDihydrofolate reductase 1.5.1.3 0.728
1dg5 TOPDihydrofolate reductase 1.5.1.3 0.703
1kms LIHDihydrofolate reductase 1.5.1.3 0.679
2w9g TOPDihydrofolate reductase 1.5.1.3 0.679
1tdr MTXDihydrofolate reductase 1.5.1.3 0.678
3jw5 TOPDihydrofolate reductase / 0.671
1lud TRRDihydrofolate reductase 1.5.1.3 0.669
1dg7 WRBDihydrofolate reductase 1.5.1.3 0.668
3fl8 RARDihydrofolate reductase / 0.661