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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3s4q NK0 Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3s4q NK0Mitogen-activated protein kinase 14 / 1.155
2rg6 287Mitogen-activated protein kinase 14 / 0.840
3mvm 39PMitogen-activated protein kinase 14 / 0.816
3d7z GK5Mitogen-activated protein kinase 14 / 0.792
3rin I2OMitogen-activated protein kinase 14 / 0.792
3iph G11Mitogen-activated protein kinase 14 / 0.784
3mvl 38PMitogen-activated protein kinase 14 / 0.760
3e92 G6AMitogen-activated protein kinase 14 / 0.759
4aa5 NQBMitogen-activated protein kinase 14 / 0.759
3itz P66Mitogen-activated protein kinase 14 / 0.744
3u8w 09JMitogen-activated protein kinase 14 / 0.739
3e93 19BMitogen-activated protein kinase 14 / 0.734
4kip 1R9Mitogen-activated protein kinase 14 / 0.729
3bx5 304Mitogen-activated protein kinase 14 / 0.727
3l8x N4DMitogen-activated protein kinase 14 / 0.726
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.722
2rg5 279Mitogen-activated protein kinase 14 / 0.718
3fkl FKLMitogen-activated protein kinase 14 / 0.712
3dt1 P40Mitogen-activated protein kinase 14 / 0.709
4c8b 0LIReceptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.703
4kin 1M8Mitogen-activated protein kinase 14 / 0.701
3d83 GK6Mitogen-activated protein kinase 14 / 0.690
3gvu STIAbelson tyrosine-protein kinase 2 2.7.10.2 0.680
3gfe P37Mitogen-activated protein kinase 14 / 0.676
4ckr DI1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.676
3kq7 KQ7Mitogen-activated protein kinase 14 / 0.673
4v01 0LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b / 0.668
5hid B1ESerine/threonine-protein kinase B-raf 2.7.11.1 0.667
3nnu EDBMitogen-activated protein kinase 14 / 0.666
4tyj 0LIFibroblast growth factor receptor 4 2.7.10.1 0.666
4aa0 AA0Mitogen-activated protein kinase 14 / 0.665
2hiw 7MPTyrosine-protein kinase ABL1 2.7.10.2 0.661
4qrc 0LIFibroblast growth factor receptor 4 2.7.10.1 0.661
1ove 358Mitogen-activated protein kinase 14 / 0.659
3bv3 P39Mitogen-activated protein kinase 14 / 0.659
2zb1 GK4Mitogen-activated protein kinase 14 / 0.657
2e2b 406Tyrosine-protein kinase ABL1 2.7.10.2 0.656
3ocg OCGMitogen-activated protein kinase 14 / 0.656
2hyy STITyrosine-protein kinase ABL1 2.7.10.2 0.653
3fsf FSSMitogen-activated protein kinase 14 / 0.653
5dro ZH2UDP-3-O-acyl-N-acetylglucosamine deacetylase / 0.651