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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qls 55V Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3qls 55VDihydrofolate reductase 1.5.1.3 1.134
4h97 53SDihydrofolate reductase 1.5.1.3 0.869
4h95 06UDihydrofolate reductase 1.5.1.3 0.765
3qly 55VUncharacterized protein / 0.757
3qlx QLRUncharacterized protein / 0.754
4ixe IXEDihydrofolate reductase 1.5.1.3 0.721
3eem 53VUncharacterized protein / 0.711
3um5 CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.707
4kak 06UDihydrofolate reductase 1.5.1.3 0.688
3qfx CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.681
1m79 MQ1Dihydrofolate reductase 1.5.1.3 0.673
3qlw N22Dihydrofolate reductase 1.5.1.3 0.659
1m7a MQUDihydrofolate reductase 1.5.1.3 0.658
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.658
1ia4 TQ6Dihydrofolate reductase 1.5.1.3 0.656
3i8a N22Dihydrofolate reductase 1.5.1.3 0.650