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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qlr QLR Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3qlr QLRDihydrofolate reductase 1.5.1.3 1.117
4h97 53SDihydrofolate reductase 1.5.1.3 0.879
3eem 53VUncharacterized protein / 0.758
1ia1 TQ3Dihydrofolate reductase 1.5.1.3 0.747
3um5 CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.742
3qlw N22Dihydrofolate reductase 1.5.1.3 0.670
4kak 06UDihydrofolate reductase 1.5.1.3 0.668
3sa2 7DRDihydrofolate reductase / 0.662
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.661
2bla CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.651