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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3p7c P7C Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3p7c P7CMitogen-activated protein kinase 14 / 1.175
3p5k P5KMitogen-activated protein kinase 14 / 0.898
3p7b P7BMitogen-activated protein kinase 14 / 0.895
3nnx EDDMitogen-activated protein kinase 14 / 0.880
3hv7 1AUMitogen-activated protein kinase 14 / 0.833
2yis YISMitogen-activated protein kinase 14 / 0.810
3nnw EDDMitogen-activated protein kinase 14 / 0.809
2yiw YIWMitogen-activated protein kinase 14 / 0.801
1w82 L10Mitogen-activated protein kinase 14 / 0.783
3nnu EDBMitogen-activated protein kinase 14 / 0.771
3o8t BMUMitogen-activated protein kinase 14 / 0.768
3hv5 R24Mitogen-activated protein kinase 14 / 0.758
3o8u BMUMitogen-activated protein kinase 14 / 0.757
3gcu R48Mitogen-activated protein kinase 14 / 0.755
3uvr 06FMitogen-activated protein kinase 14 / 0.754
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.750
3p7a P7AMitogen-activated protein kinase 14 / 0.736
3hv6 R39Mitogen-activated protein kinase 14 / 0.733
1kv1 BMUMitogen-activated protein kinase 14 / 0.732
3p79 P79Mitogen-activated protein kinase 14 / 0.732
3hv4 L51Mitogen-activated protein kinase 14 / 0.731
2puu G2GMitogen-activated protein kinase 14 / 0.728
3p78 P78Mitogen-activated protein kinase 14 / 0.727
3hv3 R49Mitogen-activated protein kinase 14 / 0.725
3gcs BAXMitogen-activated protein kinase 14 / 0.718
3gcq 1BUMitogen-activated protein kinase 14 / 0.714
3pg3 DG7Mitogen-activated protein kinase 14 / 0.705
3ugc 046Tyrosine-protein kinase JAK2 / 0.688
3oc1 BMUMitogen-activated protein kinase 14 / 0.681
1wbv LI3Mitogen-activated protein kinase 14 / 0.679
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.679
3gi3 B10Mitogen-activated protein kinase 14 / 0.677
1kv2 B96Mitogen-activated protein kinase 14 / 0.672
3o8p BMUMitogen-activated protein kinase 14 / 0.672
3dtw A96Vascular endothelial growth factor receptor 2 2.7.10.1 0.671
3lfb Z87Mitogen-activated protein kinase 14 / 0.668
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.667
3bv2 P38Mitogen-activated protein kinase 14 / 0.665
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.665
1uwh BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.661
3e93 19BMitogen-activated protein kinase 14 / 0.661
3bv3 P39Mitogen-activated protein kinase 14 / 0.659
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.659
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.657
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.654
4o2z 046Mitogen-activated protein kinase / 0.653
3lff Z83Mitogen-activated protein kinase 14 / 0.650