Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3och 2MX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3och 2MXDihydrofolate reductase 1.5.1.3 1.655
3drc MTXDihydrofolate reductase 1.5.1.3 1.053
2drc MTXDihydrofolate reductase 1.5.1.3 0.996
5hi6 MTXDihydrofolate reductase / 0.988
4dfr MTXDihydrofolate reductase 1.5.1.3 0.981
3dau MTXDihydrofolate reductase 1.5.1.3 0.963
1dra MTXDihydrofolate reductase 1.5.1.3 0.956
3ia4 MTXDihydrofolate reductase / 0.929
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.927
1df7 MTXDihydrofolate reductase 1.5.1.3 0.923
1dhj MTXDihydrofolate reductase 1.5.1.3 0.920
4p66 MTXDihydrofolate reductase / 0.895
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.887
1dhi MTXDihydrofolate reductase 1.5.1.3 0.884
1dls MTXDihydrofolate reductase 1.5.1.3 0.855
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.850
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.849
3eig MTXDihydrofolate reductase 1.5.1.3 0.843
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.840
1tdr MTXDihydrofolate reductase 1.5.1.3 0.840
2qk8 MTXDihydrofolate reductase / 0.840
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.840
1drb MTXDihydrofolate reductase 1.5.1.3 0.839
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.836
3dfr MTXDihydrofolate reductase 1.5.1.3 0.826
3tq9 MTXDihydrofolate reductase / 0.825
1jol FFODihydrofolate reductase 1.5.1.3 0.809
1u70 MTXDihydrofolate reductase 1.5.1.3 0.808
2zza FOLDihydrofolate reductase / 0.800
1dre MTXDihydrofolate reductase 1.5.1.3 0.798
3dat MTXDihydrofolate reductase / 0.786
1dyj DDFDihydrofolate reductase 1.5.1.3 0.777
1hfr MOTDihydrofolate reductase 1.5.1.3 0.768
1ohj COPDihydrofolate reductase 1.5.1.3 0.767
4qi9 MTXDihydrofolate reductase / 0.766
3frd DHFDihydrofolate reductase 1.5.1.3 0.765
4i1n FOLDihydrofolate reductase 1.5.1.3 0.765
4kjj FOLDihydrofolate reductase 1.5.1.3 0.763
1hfp MOTDihydrofolate reductase 1.5.1.3 0.758
1dyi FOLDihydrofolate reductase 1.5.1.3 0.756
5ccc DDFDihydrofolate reductase 1.5.1.3 0.756
1u72 MTXDihydrofolate reductase 1.5.1.3 0.754
1hfq MOTDihydrofolate reductase 1.5.1.3 0.750
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.750
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.742
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.740
1dyh DZFDihydrofolate reductase 1.5.1.3 0.739
4x5f FOLDihydrofolate reductase 1.5.1.3 0.738
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.736
4keb FOLDihydrofolate reductase 1.5.1.3 0.734
4x5g FOLDihydrofolate reductase 1.5.1.3 0.733
4x5i FOLDihydrofolate reductase 1.5.1.3 0.733
1e26 GPBDihydrofolate reductase 1.5.1.3 0.732
4i13 FOLDihydrofolate reductase 1.5.1.3 0.732
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.727
2w3m FOLDihydrofolate reductase 1.5.1.3 0.725
4p68 MTXDihydrofolate reductase / 0.725
1dds MTXDihydrofolate reductase 1.5.1.3 0.720
1jom FFODihydrofolate reductase 1.5.1.3 0.720
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.720
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.718
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.715
1ddr MTXDihydrofolate reductase 1.5.1.3 0.714
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.714
2d0k FOLDihydrofolate reductase 1.5.1.3 0.714
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.713
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.711
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.710
7dfr FOLDihydrofolate reductase 1.5.1.3 0.708
1dhf FOLDihydrofolate reductase 1.5.1.3 0.706
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.705
2dhf DZFDihydrofolate reductase 1.5.1.3 0.703
4x5h FOLDihydrofolate reductase 1.5.1.3 0.703
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.702
3ghv GHCDihydrofolate reductase 1.5.1.3 0.702
1drf FOLDihydrofolate reductase 1.5.1.3 0.700
4m6k FOLDihydrofolate reductase 1.5.1.3 0.697
4m6l 21VDihydrofolate reductase 1.5.1.3 0.697
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.691
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.691
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.679
1daj MOTDihydrofolate reductase 1.5.1.3 0.677
3tqb FOLDihydrofolate reductase / 0.677
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.675
1hbn TP7Methyl-coenzyme M reductase I subunit alpha 2.8.4.1 0.671
1hbn TP7Methyl-coenzyme M reductase I subunit beta 2.8.4.1 0.671
4fhb FOLDihydrofolate reductase 1.5.1.3 0.671
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.670
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.670
4kfj FOLDihydrofolate reductase 1.5.1.3 0.670
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.665
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.663
4ajn 88VL-lactate dehydrogenase A chain 1.1.1.27 0.661
3td8 D2RDihydrofolate reductase 1.5.1.3 0.658
4elf 35IDihydrofolate reductase / 0.657
2vbp VB1Isopenicillin N synthase 1.21.3.1 0.655
3fyv XCFDihydrofolate reductase 1.5.1.3 0.655
1obn ASVIsopenicillin N synthase 1.21.3.1 0.654
1qiq ACCIsopenicillin N synthase 1.21.3.1 0.653
2bjs ACVIsopenicillin N synthase 1.21.3.1 0.653
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.652
3ghw GHWDihydrofolate reductase 1.5.1.3 0.652
4bqs K2QShikimate kinase 2.7.1.71 0.652
1bk0 ACVIsopenicillin N synthase 1.21.3.1 0.651
2ivi ACWIsopenicillin N synthase 1.21.3.1 0.651