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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3o0n TTP Vitamin B12-dependent ribonucleotide reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3o0n TTPVitamin B12-dependent ribonucleotide reductase / 1.249
3o0o TTPVitamin B12-dependent ribonucleotide reductase / 1.234
1xje TTPVitamin B12-dependent ribonucleotide reductase / 1.105
3o0q TTPVitamin B12-dependent ribonucleotide reductase / 1.077
1xjj DGTVitamin B12-dependent ribonucleotide reductase / 0.943
3s87 DGTRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.900
1xjk DGTVitamin B12-dependent ribonucleotide reductase / 0.886
2cvx DGTRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.879
3s8a DGTRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.872
3k8t DGTRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.861
2wgh DTPRibonucleoside-diphosphate reductase large subunit 1.17.4.1 0.855
2eud ANPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.811
1peq TTPRibonucleoside-diphosphate reductase 2 subunit alpha 1.17.4.1 0.795
3tb9 ANPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.789
1peo DCPRibonucleoside-diphosphate reductase 2 subunit alpha 1.17.4.1 0.752
1xjn DTPVitamin B12-dependent ribonucleotide reductase / 0.726
1xjg DTPVitamin B12-dependent ribonucleotide reductase / 0.704
2cvu ANPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.699
2cvy TTPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.693
2r1r TTPRibonucleoside-diphosphate reductase 1 subunit alpha 1.17.4.1 0.693
2cvv ANPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.677
1esn ANPPantothenate kinase 2.7.1.33 0.675
4fvq ATPTyrosine-protein kinase JAK2 / 0.675
1ytm ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.673
5itz GTPTubulin alpha-1B chain / 0.667
4gvz ADPArginine kinase 2.7.3.3 0.664
3rsr N5PRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.658
4qm6 GTPMetallophosphoesterase / 0.652