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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3nwe 662 Catechol O-methyltransferase 2.1.1.6

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3nwe 662Catechol O-methyltransferase 2.1.1.6 1.294
3nwb 659Catechol O-methyltransferase 2.1.1.6 1.181
3hvi 619Catechol O-methyltransferase 2.1.1.6 1.082
3r6t LU1Catechol O-methyltransferase 2.1.1.6 1.036
3hvk 719Catechol O-methyltransferase 2.1.1.6 0.936
3nw9 637Catechol O-methyltransferase 2.1.1.6 0.922
3oe4 610Catechol O-methyltransferase 2.1.1.6 0.872
3ozt OZZCatechol O-methyltransferase 2.1.1.6 0.853
3ozs OZSCatechol O-methyltransferase 2.1.1.6 0.833
3a7d FBNCatechol O-methyltransferase 2.1.1.6 0.822
3ozr OZRCatechol O-methyltransferase 2.1.1.6 0.812
3oe5 611Catechol O-methyltransferase 2.1.1.6 0.811
1jr4 CL4Catechol O-methyltransferase 2.1.1.6 0.778
2zvj KOMCatechol O-methyltransferase 2.1.1.6 0.740
5fhq DNCCatechol O-methyltransferase 2.1.1.6 0.707
2cl5 BIECatechol O-methyltransferase 2.1.1.6 0.696
3grv ADNProbable ribosomal RNA small subunit methyltransferase A / 0.678
3u81 SAHCatechol O-methyltransferase 2.1.1.6 0.673
4pyn SAHCatechol O-methyltransferase 2.1.1.6 0.673
4xwr FADCholesterol oxidase 1.1.3.6 0.670
1y8q ATPSUMO-activating enzyme subunit 2 6.3.2 0.665
4pyo SAHCatechol O-methyltransferase 2.1.1.6 0.665
4ymg SAMPutative SAM-dependent O-methyltranferase / 0.665
4j36 FADKynurenine 3-monooxygenase / 0.660
4yuz S4MSpermidine synthase, putative / 0.660
5e8j SAHmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.659
4tlz FADKtzI / 0.658
4j2w FADKynurenine 3-monooxygenase / 0.654
3bgi SAHThiopurine S-methyltransferase 2.1.1.67 0.653
4c05 SAHProtein arginine N-methyltransferase 6 / 0.653
2ji9 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.652
2zth SAMCatechol O-methyltransferase 2.1.1.6 0.651
5ccx SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.651
4nzh FADL-ornithine N(5)-monooxygenase / 0.650
5ccb SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.650