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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3nuy JPZ 3-phosphoinositide-dependent protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3nuy JPZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.837
4oti MI1Serine/threonine-protein kinase N1 / 0.703
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.692
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.670
4c35 NU3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.665
3nuu JOZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.663
3sc1 3S13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.661
3ncz 3NCRho-associated protein kinase 1 2.7.11.1 0.654
1q8w M77cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
3mvj XFEcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.651