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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3nun JMZ 3-phosphoinositide-dependent protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3nun JMZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.960
3qcq 3Q03-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.942
3qcx 3Q23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.940
3qcy 3Q33-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.934
3qcs 3Q13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.928
3qd0 3Q43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.920
3qd3 3Q53-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.914
3qd4 3Q63-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.911
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.716
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.710
3zly YSODual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.701
3lfs A07Cyclin-dependent kinase 2 2.7.11.22 0.693
4nka 2K7Fibroblast growth factor receptor 1 / 0.690
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.686
4f64 0S8Fibroblast growth factor receptor 1 / 0.680
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.677
4agu D15Cyclin-dependent kinase-like 1 / 0.676
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.675
3r8p Z46Cyclin-dependent kinase 2 2.7.11.22 0.675
3sc1 3S13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.671
3w16 P9JAurora kinase A 2.7.11.1 0.668
2xa4 AZ5Tyrosine-protein kinase JAK2 / 0.667
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.666
3w2c N15Aurora kinase A 2.7.11.1 0.665
4e20 0MYNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.664
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.664
3lfn A27Cyclin-dependent kinase 2 2.7.11.22 0.662
3ggf GVDSerine/threonine-protein kinase 26 / 0.661
3tkh 07SSerine/threonine-protein kinase Chk1 2.7.11.1 0.661
3qql X03Cyclin-dependent kinase 2 2.7.11.22 0.659
4ez5 0RSCyclin-dependent kinase 6 2.7.11.22 0.658
2gni M77cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
4ftq 4HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.656
4bdh WVISerine/threonine-protein kinase Chk2 2.7.11.1 0.652
2pe0 39Z3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.650
2pe2 4643-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.650
4f63 0S7Fibroblast growth factor receptor 1 / 0.650