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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3npc B96 Mitogen-activated protein kinase 9 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 1.477
2yiw YIWMitogen-activated protein kinase 14 / 0.932
3hv6 R39Mitogen-activated protein kinase 14 / 0.907
3nnx EDDMitogen-activated protein kinase 14 / 0.890
2yis YISMitogen-activated protein kinase 14 / 0.840
3nnw EDDMitogen-activated protein kinase 14 / 0.831
1w82 L10Mitogen-activated protein kinase 14 / 0.821
3p5k P5KMitogen-activated protein kinase 14 / 0.815
3uvr 06FMitogen-activated protein kinase 14 / 0.812
3hv3 R49Mitogen-activated protein kinase 14 / 0.792
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.791
3p7b P7BMitogen-activated protein kinase 14 / 0.790
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.789
3p7a P7AMitogen-activated protein kinase 14 / 0.787
1kv2 B96Mitogen-activated protein kinase 14 / 0.783
2puu G2GMitogen-activated protein kinase 14 / 0.779
3hv7 1AUMitogen-activated protein kinase 14 / 0.764
3p7c P7CMitogen-activated protein kinase 14 / 0.750
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.748
3lff Z83Mitogen-activated protein kinase 14 / 0.745
3lfe Z84Mitogen-activated protein kinase 14 / 0.744
3o8u BMUMitogen-activated protein kinase 14 / 0.739
3gcq 1BUMitogen-activated protein kinase 14 / 0.737
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.731
3gcu R48Mitogen-activated protein kinase 14 / 0.723
3hv5 R24Mitogen-activated protein kinase 14 / 0.722
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.722
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.721
3hv4 L51Mitogen-activated protein kinase 14 / 0.720
3nnu EDBMitogen-activated protein kinase 14 / 0.719
3p79 P79Mitogen-activated protein kinase 14 / 0.719
3oc1 BMUMitogen-activated protein kinase 14 / 0.714
3o8t BMUMitogen-activated protein kinase 14 / 0.713
1kv1 BMUMitogen-activated protein kinase 14 / 0.711
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.708
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.707
3gcv SS6Mitogen-activated protein kinase 14 / 0.706
3p78 P78Mitogen-activated protein kinase 14 / 0.695
3fzs B96Protein-tyrosine kinase 2-beta 2.7.10.2 0.685
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 0.682
1uwh BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.679
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.676
1wbv LI3Mitogen-activated protein kinase 14 / 0.673
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.673
3fzt 4JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.670
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.665
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.664
3uvp 048Mitogen-activated protein kinase 14 / 0.660
4f7l 0SOCyclin-dependent kinase 8 2.7.11.22 0.654
3nww 3NWMitogen-activated protein kinase 14 / 0.651