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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3mzh CMP CRP-like cAMP-activated global transcriptional regulator

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3mzh CMPCRP-like cAMP-activated global transcriptional regulator / 0.941
4ev0 CMPCyclic AMP receptor protein / 0.694
4qx5 CMPcGMP-dependent protein kinase 1 2.7.11.12 0.687
2ptm CMPHyperpolarization-activated (Ih) channel / 0.665
4ku7 PCGcGMP-dependent protein kinase 1 2.7.11.12 0.664
2cgp CMPcAMP-activated global transcriptional regulator CRP / 0.659
3i59 N6RCRP-like cAMP-activated global transcriptional regulator / 0.659
3i59 N6SCRP-like cAMP-activated global transcriptional regulator / 0.657
3u0z CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 / 0.657
1hw5 CMPcAMP-activated global transcriptional regulator CRP / 0.650
2oz6 CMPCyclic AMP receptor-like protein / 0.650