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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3mtf A3F Activin receptor type-1 2.7.11.30

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3mtf A3FActivin receptor type-1 2.7.11.30 1.069
4bgg 844Activin receptor type-1 2.7.11.30 0.997
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
5hes 032Mitogen-activated protein kinase kinase kinase 20 2.7.11.25 0.694
4mxo DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.687
3vs3 VSETyrosine-protein kinase HCK 2.7.10.2 0.670
1yol S03Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.665
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.664
1lud TRRDihydrofolate reductase 1.5.1.3 0.663
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.663
3v04 V04Dual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.662
4e5f 0N7Polymerase acidic protein / 0.660
4hjo AQ4Epidermal growth factor receptor 2.7.10.1 0.657
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.656
2wou ZZFTGF-beta receptor type-1 2.7.11.30 0.653
3cqe P91Wee1-like protein kinase 2.7.10.2 0.652