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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3m08 RAR Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3m08 RARDihydrofolate reductase 1.5.1.3 1.277
3m09 RARDihydrofolate reductase 1.5.1.3 1.126
4fgg 0U5Dihydrofolate reductase 1.5.1.3 0.959
2w9g TOPDihydrofolate reductase 1.5.1.3 0.849
4elf 35IDihydrofolate reductase / 0.849
4elg 52JDihydrofolate reductase / 0.849
3fl8 RARDihydrofolate reductase / 0.831
4ele 31IDihydrofolate reductase / 0.811
4fgh 0U6Dihydrofolate reductase 1.5.1.3 0.797
3fra I2HDihydrofolate reductase 1.5.1.3 0.789
3fyv XCFDihydrofolate reductase 1.5.1.3 0.785
3fy9 XCFDihydrofolate reductase 1.5.1.3 0.763
3fyw XCFDihydrofolate reductase 1.5.1.3 0.721
2w3v TOPDihydrofolate reductase / 0.716
3srs M23Dihydrofolate reductase 1.5.1.3 0.711
2qk8 MTXDihydrofolate reductase / 0.677
3fy8 XCFDihydrofolate reductase 1.5.1.3 0.677
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.675
3dat MTXDihydrofolate reductase / 0.667
3sr5 Q12Dihydrofolate reductase 1.5.1.3 0.661
4qi9 MTXDihydrofolate reductase / 0.660