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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3lfe Z84 Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3lfe Z84Mitogen-activated protein kinase 14 / 1.091
3lfb Z87Mitogen-activated protein kinase 14 / 0.865
3pg3 DG7Mitogen-activated protein kinase 14 / 0.865
3hv6 R39Mitogen-activated protein kinase 14 / 0.853
3hv3 R49Mitogen-activated protein kinase 14 / 0.836
3hv7 1AUMitogen-activated protein kinase 14 / 0.828
3lff Z83Mitogen-activated protein kinase 14 / 0.819
3gcq 1BUMitogen-activated protein kinase 14 / 0.816
3lfc Z86Mitogen-activated protein kinase 14 / 0.808
3uvr 06FMitogen-activated protein kinase 14 / 0.779
1kv2 B96Mitogen-activated protein kinase 14 / 0.777
4twn B96Ephrin type-A receptor 3 2.7.10.1 0.764
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.757
3hv5 R24Mitogen-activated protein kinase 14 / 0.754
3p5k P5KMitogen-activated protein kinase 14 / 0.746
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2puu G2GMitogen-activated protein kinase 14 / 0.742
3o8p BMUMitogen-activated protein kinase 14 / 0.742
3gcu R48Mitogen-activated protein kinase 14 / 0.735
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.733
3hv4 L51Mitogen-activated protein kinase 14 / 0.730
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.727
3p7b P7BMitogen-activated protein kinase 14 / 0.725
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.725
2yis YISMitogen-activated protein kinase 14 / 0.715
3o8u BMUMitogen-activated protein kinase 14 / 0.707
3nnx EDDMitogen-activated protein kinase 14 / 0.705
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.705
2yiw YIWMitogen-activated protein kinase 14 / 0.704
4f70 0STCyclin-dependent kinase 8 2.7.11.22 0.703
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 0.702
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.702
3gi3 B10Mitogen-activated protein kinase 14 / 0.700
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.697
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.685
3fzt 4JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.684
3gcs BAXMitogen-activated protein kinase 14 / 0.683
3fzs B96Protein-tyrosine kinase 2-beta 2.7.10.2 0.681
3p79 P79Mitogen-activated protein kinase 14 / 0.678
1w82 L10Mitogen-activated protein kinase 14 / 0.671
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.671
3nnw EDDMitogen-activated protein kinase 14 / 0.668
3p7a P7AMitogen-activated protein kinase 14 / 0.664
3o8t BMUMitogen-activated protein kinase 14 / 0.663
4e5f 0N7Polymerase acidic protein / 0.660
2oh4 GIGVascular endothelial growth factor receptor 2 2.7.10.1 0.658
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.658