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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3k45 51P Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3k45 51PDihydrofolate reductase 1.5.1.3 0.912
3gyf 51PDihydrofolate reductase 1.5.1.3 0.809
3cse N22Uncharacterized protein / 0.774
3eel 53TUncharacterized protein / 0.744
3nxo D2BDihydrofolate reductase 1.5.1.3 0.741
3k47 D09Dihydrofolate reductase 1.5.1.3 0.739
4ixg IXGDihydrofolate reductase 1.5.1.3 0.726
3qlz QLZUncharacterized protein / 0.724
4kak 06UDihydrofolate reductase 1.5.1.3 0.723
4kd7 9DRDihydrofolate reductase 1.5.1.3 0.698
3oaf OAGDihydrofolate reductase 1.5.1.3 0.685
4g95 OAGDihydrofolate reductase 1.5.1.3 0.684
3nxt D2EDihydrofolate reductase 1.5.1.3 0.682
3eej 53RUncharacterized protein / 0.679
1m78 CLZDihydrofolate reductase 1.5.1.3 0.672
3td8 D2RDihydrofolate reductase 1.5.1.3 0.668
3um5 CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.666
3l3r OAGDihydrofolate reductase 1.5.1.3 0.664
3eem 53VUncharacterized protein / 0.662
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.656
3s7a 684Dihydrofolate reductase 1.5.1.3 0.655
4ixe IXEDihydrofolate reductase 1.5.1.3 0.654
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.653
4p68 MTXDihydrofolate reductase / 0.651