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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3jwc EKB Dihydrofolate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3jwc EKBDihydrofolate reductase / 1.044
3sai 9DRDihydrofolate reductase / 0.816
3sa1 6DRDihydrofolate reductase / 0.793
4h95 06UDihydrofolate reductase 1.5.1.3 0.698
4kd7 9DRDihydrofolate reductase 1.5.1.3 0.686
3jwm 5WBDihydrofolate reductase / 0.678
4p68 MTXDihydrofolate reductase / 0.671
4h97 53SDihydrofolate reductase 1.5.1.3 0.669
2w9g TOPDihydrofolate reductase 1.5.1.3 0.665
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.662