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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3jsu KA5 Bifunctional dihydrofolate reductase-thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3jsu KA5Bifunctional dihydrofolate reductase-thymidylate synthase / 1.045
1m78 CLZDihydrofolate reductase 1.5.1.3 0.730
1mvt DTMDihydrofolate reductase 1.5.1.3 0.707
1aoe GW3Dihydrofolate reductase 1.5.1.3 0.678
1u71 MXADihydrofolate reductase 1.5.1.3 0.667
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.662
1kms LIHDihydrofolate reductase 1.5.1.3 0.657
4dph P65Bifunctional dihydrofolate reductase-thymidylate synthase / 0.657
1e26 GPBDihydrofolate reductase 1.5.1.3 0.653
1mvs DTMDihydrofolate reductase 1.5.1.3 0.653
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.651
4p68 MTXDihydrofolate reductase / 0.650