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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3hzt J60 Calmodulin-like domain protein kinase isoform 3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3hzt J60Calmodulin-like domain protein kinase isoform 3 / 0.984
4e5i 0N9Polymerase acidic protein / 0.744
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.727
4agd B49Vascular endothelial growth factor receptor 2 2.7.10.1 0.693
4jlc SU6Serine/threonine-protein kinase TBK1 2.7.11.1 0.692
4qmz B49Serine/threonine-protein kinase 24 2.7.11.1 0.692
1fvt 106Cyclin-dependent kinase 2 2.7.11.22 0.684
2x2k X2KProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.683
1p2a 5BNCyclin-dependent kinase 2 2.7.11.22 0.682
3g0e B49Mast/stem cell growth factor receptor Kit 2.7.10.1 0.682
3py0 SU9Cyclin-dependent kinase 2 2.7.11.22 0.682
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.680
4qmt H1NSerine/threonine-protein kinase 24 2.7.11.1 0.677
1uv5 BRWGlycogen synthase kinase-3 beta 2.7.11.26 0.674
2f7e 2EAcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
5dgz L20Serine/threonine-protein kinase pim-1 2.7.11.1 0.672
4fsq HK3Serine/threonine-protein kinase Chk1 2.7.11.1 0.669
3g0f B49Mast/stem cell growth factor receptor Kit 2.7.10.1 0.668
1ke5 LS1Cyclin-dependent kinase 2 2.7.11.22 0.667
3l9m L9McAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
3c7q XINVascular endothelial growth factor receptor 2 2.7.10.1 0.663
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.661
3l9n L9NcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
1pmn 984Mitogen-activated protein kinase 10 2.7.11.24 0.660
4e5f 0N7Polymerase acidic protein / 0.660
1ke6 LS2Cyclin-dependent kinase 2 2.7.11.22 0.659
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.656
4fx3 60KCyclin-dependent kinase 2 2.7.11.22 0.656
2vz6 FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha 2.7.11.17 0.654
2uzu L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
2hiw 7MPTyrosine-protein kinase ABL1 2.7.10.2 0.651
3sr5 Q12Dihydrofolate reductase 1.5.1.3 0.650