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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gvh NAD Malate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3gvh NADMalate dehydrogenase / 0.970
1pzh NADLactate dehydrogenase / 0.760
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.756
1sow NADL-lactate dehydrogenase 1.1.1.27 0.742
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.740
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.738
2aa3 AP0L-lactate dehydrogenase / 0.733
2a92 NAIL-lactate dehydrogenase / 0.732
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.729
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.718
1wzi NDPMalate dehydrogenase / 0.714
1uxj NADMalate dehydrogenase / 0.711
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.708
1uxk NADMalate dehydrogenase / 0.699
1b8v NADMalate dehydrogenase / 0.697
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.695
1pzg A3DLactate dehydrogenase / 0.694
1pzf A3DLactate dehydrogenase / 0.691
2d8a NADL-threonine 3-dehydrogenase / 0.689
4i1i NADMalate dehydrogenase / 0.689
5a1t NAIL-lactate dehydrogenase / 0.687
1bmd NADMalate dehydrogenase / 0.686
1ib6 NADMalate dehydrogenase / 0.679
4ros APRMalate dehydrogenase / 0.679
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.678
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.678
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.675
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.668
1o6z NADMalate dehydrogenase / 0.668
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.668
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.667
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.663
4j43 NADUncharacterized protein / 0.663
1ie3 NADMalate dehydrogenase / 0.662
1bdm NAXMalate dehydrogenase / 0.661
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.659
3kbo NDPGlyoxylate/hydroxypyruvate reductase A / 0.659
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.658
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.657
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.655
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.654
1gv0 NADMalate dehydrogenase / 0.654
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.654
1h2h NADL-aspartate dehydrogenase 1.4.1.21 0.653
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.653
2dfv NADL-threonine 3-dehydrogenase / 0.652
1x7d NADPutative ornithine cyclodeaminase / 0.651
2x0i NAIMalate dehydrogenase / 0.650