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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gr8 FMN NADPH dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3gr8 FMNNADPH dehydrogenase / 1.224
1z48 FMNNADPH dehydrogenase / 1.124
1z44 FMNNADPH dehydrogenase / 1.085
3hf3 FMNChromate reductase / 1.076
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 1.069
1z41 FMNNADPH dehydrogenase / 1.049
4utm FNRXenobiotic reductase / 0.972
3n14 FMNXenobiotic reductase / 0.946
3l67 FMNXenobiotic reductase / 0.941
4uth FMNXenobiotic reductase / 0.939
4utl FNRXenobiotic reductase / 0.936
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.927
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.926
4utk FNRXenobiotic reductase / 0.910
2h8x FMNXenA / 0.904
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.897
3l5l FMNXenobiotic reductase / 0.892
4m5p FMNNADPH dehydrogenase / 0.885
5cpm FNRNADH:flavin oxidoreductase / 0.870
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.867
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.865
3tjl FMNNADPH dehydrogenase / 0.860
4yco FMNtRNA-dihydrouridine(16) synthase / 0.857
4df2 FMNNADPH dehydrogenase / 0.852
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.842
1vhn FMNtRNA-dihydrouridine synthase / 0.842
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.842
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.828
1vyr FMNPentaerythritol tetranitrate reductase / 0.815
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.814
3p8j FMNPentaerythritol tetranitrate reductase / 0.811
1gwj FMNMorphinone reductase / 0.810
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.807
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.805
3p67 FMNPentaerythritol tetranitrate reductase / 0.805
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.800
4tmc FMNOld yellow enzyme / 0.799
3gka FMNN-ethylmaleimide reductase / 0.792
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.784
2abb FMNPentaerythritol tetranitrate reductase / 0.779
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.779
4e2d FMNDehydrogenase / 0.777
1h51 FMNPentaerythritol tetranitrate reductase / 0.772
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.771
3aty FMNProstaglandin F2a synthase / 0.767
2z6i FMN2-nitropropane dioxygenase / 0.765
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.762
2nli FMNLactate oxidase / 0.762
1h50 FMNPentaerythritol tetranitrate reductase / 0.761
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.759
4jic FMNGTN Reductase / 0.758
3p84 FMNPentaerythritol tetranitrate reductase / 0.752
3p8i FMNPentaerythritol tetranitrate reductase / 0.752
3f03 FMNPentaerythritol tetranitrate reductase / 0.751
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.748
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.747
2j6x FMNLactate oxidase / 0.747
2zfa FMNLactate oxidase / 0.747
3n19 FNRXenobiotic reductase / 0.745
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.745
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.741
4e2b FMNDehydrogenase / 0.741
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.741
3oix FMNDihydroorotate dehydrogenase / 0.738
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 0.734
3atz FMNProstaglandin F2a synthase / 0.730
3p82 FMNPentaerythritol tetranitrate reductase / 0.730
4qai FMNNADPH dehydrogenase / 0.730
1lm1 FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.728
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.728
3p62 FMNPentaerythritol tetranitrate reductase / 0.726
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.716
3gye FMNDihydroorotate dehydrogenase (fumarate) / 0.715
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.712
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.711
3p74 FMNPentaerythritol tetranitrate reductase / 0.710
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 0.710
1llw FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.709
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.707
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.704
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.703
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.701
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.700
4z38 FMNMlnA / 0.698
3b04 OOPIsopentenyl-diphosphate delta-isomerase / 0.693
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.689
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.687
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.683
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.683
4tmb FMNOld yellow enzyme / 0.680
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.678
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.675
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.672
2ji6 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.667
1ea0 FMNGlutamate synthase [NADPH] large chain 1.4.1.13 0.663
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.662
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.657
4cw5 FMNDfnA / 0.657
1h63 FMNPentaerythritol tetranitrate reductase / 0.656
2jib ADPOxalyl-CoA decarboxylase 4.1.1.8 0.652
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.650
2du2 FMNLactate oxidase / 0.650
4yl2 FMNLactate oxidase / 0.650