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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ghv GHC Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3ghv GHCDihydrofolate reductase 1.5.1.3 1.202
3ghw GHWDihydrofolate reductase 1.5.1.3 1.018
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.995
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.867
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.858
2w3m FOLDihydrofolate reductase 1.5.1.3 0.799
4m6k FOLDihydrofolate reductase 1.5.1.3 0.796
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.781
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.780
4x5f FOLDihydrofolate reductase 1.5.1.3 0.761
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.752
1dyi FOLDihydrofolate reductase 1.5.1.3 0.747
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.742
3drc MTXDihydrofolate reductase 1.5.1.3 0.735
4p68 MTXDihydrofolate reductase / 0.733
4i13 FOLDihydrofolate reductase 1.5.1.3 0.728
2drc MTXDihydrofolate reductase 1.5.1.3 0.726
1dhf FOLDihydrofolate reductase 1.5.1.3 0.725
4m6l 21VDihydrofolate reductase 1.5.1.3 0.722
5ccc DDFDihydrofolate reductase 1.5.1.3 0.721
1e26 GPBDihydrofolate reductase 1.5.1.3 0.719
1hfq MOTDihydrofolate reductase 1.5.1.3 0.715
1hfr MOTDihydrofolate reductase 1.5.1.3 0.714
3dfr MTXDihydrofolate reductase 1.5.1.3 0.704
1dre MTXDihydrofolate reductase 1.5.1.3 0.703
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.703
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.703
1dhj MTXDihydrofolate reductase 1.5.1.3 0.702
3och 2MXDihydrofolate reductase 1.5.1.3 0.702
5hi6 MTXDihydrofolate reductase / 0.700
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.697
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.692
1dls MTXDihydrofolate reductase 1.5.1.3 0.689
4x5g FOLDihydrofolate reductase 1.5.1.3 0.689
1dyj DDFDihydrofolate reductase 1.5.1.3 0.687
1dra MTXDihydrofolate reductase 1.5.1.3 0.686
1ohj COPDihydrofolate reductase 1.5.1.3 0.683
4keb FOLDihydrofolate reductase 1.5.1.3 0.683
4i1n FOLDihydrofolate reductase 1.5.1.3 0.681
1drb MTXDihydrofolate reductase 1.5.1.3 0.680
2d0k FOLDihydrofolate reductase 1.5.1.3 0.680
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.674
4fhb FOLDihydrofolate reductase 1.5.1.3 0.672
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.671
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.671
2zza FOLDihydrofolate reductase / 0.671
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.670
4kfj FOLDihydrofolate reductase 1.5.1.3 0.668
1x28 PGUAspartate aminotransferase 2.6.1.1 0.667
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.666
3ia4 MTXDihydrofolate reductase / 0.665
4qi9 MTXDihydrofolate reductase / 0.665
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.663
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.663
1ohk COPDihydrofolate reductase 1.5.1.3 0.662
3eig MTXDihydrofolate reductase 1.5.1.3 0.662
1odn APVIsopenicillin N synthase 1.21.3.1 0.660
7dfr FOLDihydrofolate reductase 1.5.1.3 0.660
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.659
1dr3 HBIDihydrofolate reductase 1.5.1.3 0.658
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.657
4dfr MTXDihydrofolate reductase 1.5.1.3 0.657
4kjj FOLDihydrofolate reductase 1.5.1.3 0.654
1jom FFODihydrofolate reductase 1.5.1.3 0.653
1drf FOLDihydrofolate reductase 1.5.1.3 0.652
1u70 MTXDihydrofolate reductase 1.5.1.3 0.650