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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gcs BAX Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3gcs BAXMitogen-activated protein kinase 14 / 1.266
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.822
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.817
3o8t BMUMitogen-activated protein kinase 14 / 0.792
3o8p BMUMitogen-activated protein kinase 14 / 0.789
3o8u BMUMitogen-activated protein kinase 14 / 0.782
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.780
3ugc 046Tyrosine-protein kinase JAK2 / 0.777
3oc1 BMUMitogen-activated protein kinase 14 / 0.764
2hzn KINTyrosine-protein kinase ABL1 2.7.10.2 0.748
3p79 P79Mitogen-activated protein kinase 14 / 0.721
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.721
3p7c P7CMitogen-activated protein kinase 14 / 0.718
4u0i 0LIMast/stem cell growth factor receptor Kit 2.7.10.1 0.710
3el8 PD5Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.706
3gi3 B10Mitogen-activated protein kinase 14 / 0.702
3hv3 R49Mitogen-activated protein kinase 14 / 0.700
4o2z 046Mitogen-activated protein kinase / 0.700
3p78 P78Mitogen-activated protein kinase 14 / 0.698
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.689
2hz0 GINTyrosine-protein kinase ABL1 2.7.10.2 0.688
3gcq 1BUMitogen-activated protein kinase 14 / 0.688
4jbp YPHAurora kinase A 2.7.11.1 0.686
1w82 L10Mitogen-activated protein kinase 14 / 0.685
2ofv 242Tyrosine-protein kinase Lck 2.7.10.2 0.684
3lfe Z84Mitogen-activated protein kinase 14 / 0.683
4agw NG7Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.683
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.679
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.677
3lfb Z87Mitogen-activated protein kinase 14 / 0.675
2qu6 857Vascular endothelial growth factor receptor 2 2.7.10.1 0.673
2oh4 GIGVascular endothelial growth factor receptor 2 2.7.10.1 0.670
4jbo WPHAurora kinase A 2.7.11.1 0.662
1wbv LI3Mitogen-activated protein kinase 14 / 0.661
3gcu R48Mitogen-activated protein kinase 14 / 0.661
4at4 T6EBDNF/NT-3 growth factors receptor 2.7.10.1 0.661
2yis YISMitogen-activated protein kinase 14 / 0.659
3tub FPUTyrosine-protein kinase SYK 2.7.10.2 0.659
3b8q 900Vascular endothelial growth factor receptor 2 2.7.10.1 0.656
3vw8 DF6Hepatocyte growth factor receptor 2.7.10.1 0.656
3d83 GK6Mitogen-activated protein kinase 14 / 0.655
2yiw YIWMitogen-activated protein kinase 14 / 0.654
3hv6 R39Mitogen-activated protein kinase 14 / 0.652
3hv5 R24Mitogen-activated protein kinase 14 / 0.650
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.650